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Functional enrichments were established using the Gene Ontology (GO) biological processes, the GO molecular functions and the GO cellular components, STRING local network clusters, the KEGG pathways, Reactome pathways (the European Bioinformatics Institute Pathway Database) 10 , PANTHER biological processes (PANTHER---Gene List Analysis) 11 , TTRUST transcriptional regulatory relationships, InterPro domains (InterPro) 12 , Wikipathways (WikiPathways - WikiPathways), and DOID annotations of human diseases (Disease Ontology---Institute for Genome Sciences, University of Maryland) 13

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