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In PCOS where insulin resistance is present in up to 80% of affected women regardless of body weight GLP-1 agonists have demonstrated measurable reductions in free testosterone, improved menstrual regularity, and significant metabolic benefit

10.1016/j.intimp.2015.05.045 11 Arky Jane LangstiehJ

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Preclinical data also associate this signaling activity with lipolytic effects the mobilization of stored fat for use as an energy substrate which is one reason the compound appears in research examining body composition and metabolic regulation rather than muscle biology alone, a research area covered in more depth in our overview of the best peptides for fat loss