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In some embodiments, a paper patch myringoplasty is performed by a trained physician

Different shapes, materials, and techniques of prosthetic repair and the use of relaxing incisions have been proposed, but long-term data are lacking, and no conclusions can be drawn regarding the ideal method of crural closure

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The transition from observing natural NPY as a biomarker to using exogenous NPY as a treatment involves assumptions about dose-response relationships that have not been fully validated in human trials