Some people may tolerate tirzepatide better, while others tolerate semaglutide with fewer problems
Reference Novo Nordisk A/S: Wegovy pill approved in the US as first oral GLP-1 for weight management, 23 December 2025, Can oral Semaglutide (Wegovy) 25 mg replace the Once-Weekly 2.4 mg Injection for Obesity?, 25 September 2025, Research Study Looking at How Well Semaglutide Tablets Taken Once Daily Work in People Who Have a Body Weight Above the Healthy Range (OASIS 4), ClinicalTrials.gov ID NCT05564117, Wharton S, Lingvay I, Bogdanski P, Duque do Vale R, Jacob S, Karlsson T, Shaji C, Rubino D, Garvey WT
Hypercholesterolemia is captured by E78.0
UHC does step therapy for Wegovy on some plans, requiring phentermine or Contrave first