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Antidiabetic exendin-4 activates apoptotic pathway and inhibits growth of breast cancer cells

Similarly, 100nM Semaglutide promoted osteogenesis in rat BMSC via WNT-beta-Catenin signaling, which resulted in promoted mineral deposition and RUNX2/OCN gene expression [30]

A 2025 review in Endocrinology found that endogenous sex hormones estrogen in particular modulate GLP-1 receptor expression in the hypothalamus, and that women experience both greater weight loss and higher rates of side effects than men on GLP-1 agonists