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Enzyme sources Pooled subcellular fractions of male Sprague-Dawley rat liver S9 fractions (10 donors), male Sprague-Dawley Aroclor 1254 induced rat liver S9 fractions (20 donors), human liver S9 fractions (mixed gender 10 donors), male Gottingen minipig liver microsomes (3 donors) and male Gottingen minipig liver S9 fractions (3 donors) were purchased from BioreclamationIVT (West Sussex, UK)

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Participants were eligible to be included in the trial only if all of the following criteria applied: Informed consent obtained before any trial-related activities

These potential advantages are class-level expectations for small-molecule GLP-1RAs, rather than established price outcomes