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In a study (New-Onset Nonarteritic Anterior Ischemic Optic Neuropathy and Initiators of Semaglutide in US Veterans With Type 2 Diabetes) published on February 12, 2026, participants who started taking semaglutide were about 2 times more likely to develop NAION than participants who took sodium-glucose cotransporter-2 inhibitors

Light-induced degradation can cause yellowing, which is why a vial that was perfectly clear when it arrived might develop a yellow tint over weeks if repeatedly exposed to light during each injection session

The retatrutide versus semaglutide comparison and the broader landscape of tirzepatide alternatives provide context for evaluating which medication best suits individual needs

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