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Covariate balance was considered satisfactory when the standardized mean difference (SMD) was less than 0.1 ( The selection of baseline covariates was informed by prior literature and clinical relevance, with the aim of capturing key demographic characteristics, comorbid conditions, and laboratory parameters that are known or plausibly associated with both treatment allocation and the risk of venous thromboembolism

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According to the policy of the Animal Experimentation Ethics Committee of China Pharmaceutical University, such minimal-risk procedures are exempt from ethical approval