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Notably, the MTHFR rs1801133 TT genotype has been associated with higher PASI 90 response rates, indicating better therapeutic outcomes, while the CT + TT genotypes correlate with an increased risk of liver function abnormalities in patients with psoriatic arthritis (Zhu et al

In brain, the properties of GSH transport in isolated rat brain mitochondria seemed to be different from those reported previously for kidney mitochondria, as they were influenced most by inhibitors of the tricarboxylate carrier, citrate, isocitrate, and benzenyl-1,2,3-tricarboxylate (Wadey et al., 2009)

Some patients benefit from stepping down to a lower maintenance dose rather than stopping completely

Many studies highlight potential benefits in improving insulin sensitivity, glucose metabolism, and lipid profiles, but inconsistencies in dosing, study duration, and methodology limit definitive conclusions