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Moreover, the expression of signal transducer and activator of transcription 5A ( STAT5A) , an essential mediator of IL-2 signaling in T-cells ( Figure 6 Most intriguingly, the expression of T H 17-related genes such as IL17A, IL17F, IL22 , and B-cell activating transcription factor (BATF) was strongly decreased by SFN, while T H 1, T H 2 or Treg related genes, i.e., STAT4, IL-4 , and FOXP3 were no major targets of SFN (Figure 6C)

In addition, the small leucine-rich repeat proteoglycan of bone extracellular matrix tissue biglycan, which is correlated with an aggressive phenotype of osteosarcoma, supported tumor growth and induced resistance to chemotherapy drug doxorubicin by forming a complex with IGF-1R leading to activation of the IGF-1R signaling pathway in human osteosarcoma cell line MG63 (37)

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