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The Endocrine Society reports that up to 40% of weight loss from semaglutide can come from lean body mass if you don't manage your nutrition carefully

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Its evidence base runs deep: in type-2 diabetes (SUSTAIN1) semaglutide cut HbA1c by 1.55 points[2], and in the 17,604-patient SELECT cardiovascular trial it reduced major cardiac events by 20% in adults with obesity and no diabetes[3]

The drug has been approved for treating obesity by major regulatory authorities, including the FDA in the United States and the EMA in Europe in June 2021 and January 2022, respectively