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Annu Rev Nutr 27:415430

Recent findings suggest that many of the memory enhancing effects originally attributed to AngII acting at the AT1 receptor subtype were due to the conversion of AngII to angiotensin III (AngIII) and then to the hexapeptide angiotensin IV (Ang IV) and it were AngIV activation of the AT4 receptor subtype that facilitated memory consolidation and retrieval [62-64]

The difference is dose size and speed of delivery, not the underlying biology

We stated that as of the CY 2026 PFS proposed rule, data was collected using a mail-phone survey administration protocol administered in English and Spanish, with additional translations available