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Who Should Communicate with Their Provider Before Starting Both Medications Patients with severe baseline gastrointestinal disorders, such as inflammatory bowel disease, gastroparesis, or chronic pancreatitis, should alert their provider before combining these medications

Current guidance recommends stopping GLP-1 medications before conception and avoiding use during pregnancy due to insufficient safety data

The GLP-1 and GIP tolerance you built on tirzepatide is relevant, but the glucagon component is a wild card

These data indicate that the increase in GLP-1 after glucose challenge or feeding in mice lacking Pam is not due to altered L-cell densities, differences in GLP-1 production or DPP4 activity, but rather to altered GLP-1 secretion