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Both are dual agonists designed to produce superior weight loss compared to single-receptor medications like semaglutide , but their different receptor combinations create distinct metabolic effects, side effect profiles, and practical considerations that matter when choosing between them

Most patients receiving the combination of two RAS inhibitors do not obtain any additional benefit compared to monotherapy

Adult hepatologists must increase awareness of these diseases because paediatric patients are increasingly likely to reach adulthood with their native liver, and because several adult cholestatic diseases are likely associated with the same genes as PFIC

While severe inborn errors of folate metabolismsuch as those causing homocystinuriaare rare and typically result from deletions or deleterious mutations that abolish enzyme function, their dramatic clinical consequences have underscored the critical importance of this metabolic pathway [1-3]