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GLP-1R signaling on microglia attenuates neuroinflammation by suppressing the polarization of microglia to a proinflammatory state, wrote the authors

Eli Lilly is studying retatrutide in several phase-3 clinical trials for obesity, type-2 diabetes, knee osteoarthritis pain, moderate-to-severe obstructive sleep apnea, chronic low back pain, cardiovascular and renal outcomes, and metabolic dysfunction-associated steatosis liver disease