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Other animal models of FM include the chronic constriction injury model, which involves the compression of a nerve to induce neuropathic pain 37 , and the ovariectomy model, which involves the removal of the ovaries to induce hormonal changes that may be associated with FM 37

The Trx system functions through thiol-disulphide interchange reactions, contributing to many essential cellular functions, such as gene expression [66], DNA synthesis [67], signal transduction [68], cell growth and apoptosis [69]

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