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Upon receptor binding, MT1 triggers the cAMP signaling cascade, upregulating the enzyme tyrosinase and increasing the production of eumelanin the dark, UV-protective form of melanin

(Source 2) Please note that more iron isn't better as too much can be inflammatory, so it's best to work with your functional medicine provider for proper testing and guidance

All experiments were conducted in a buffer solution containing 20 mM HEPES (pH 7.0), 150 mM NaCl, 1 mM dithiothreitol (DTT), and 5% dimethyl sulfoxide (DMSO)

Lustig RH, Pfaff DW, Fishman J: Opioidergic modulation of the oestradiol-induced LH surge in the rat: roles of ovarian steroids