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According to the hematoxylin and eosin (HE) staining, tartrate-resistant acid phosphatase (TRAP) staining, and Safranin O/Fast green (SO/FG) staining, the ankle joint tissues in the saline group exhibited extensive inflammatory cell infiltration, synovial hyperplasia, severe bone erosion, and cartilage destruction (Fig

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In addition to improving diabetes-related symptoms, GLP-1 drugs also reduce inflammatory cells and factors through multiple signaling pathways, increase the expression of anti-inflammatory factors and alleviate inflammatory responses