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doi: 10.1111/j.1755-5922.2010.00256.x 30 SattarNLeeMMYKristensenSLBranchKRHDel PratoSKhurmiNSet al

Excretion Pathways Limited data on combined excretion indicates: Primarily renal elimination of peptide fragments Hepatic metabolism contributes to overall clearance Copper recycling through normal physiological pathways No evidence of accumulation in chronic dosing studies (animal models) The relationship between rapid plasma clearance and prolonged biological effects represents a key area requiring further mechanistic investigation across all three components

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These dogs were mostly neutered and were being fed a variety of quality commercial diets