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Selhub and Miller, 1992) and by our laboratory in animal models (Durand et al, 1997a), has facilitated the understanding of mechanisms leading to hyperhomocysteinemia
ER-associated degradation A cellular quality-control system that ensures removal of misfolded and/or unassembled proteins from the endoplasmic-reticulum lumen and their subsequent elimination by the cytoplasmic ubiquitinproteasome system
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