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doi:10.1016/j.dsx.2016.06.024 Li K, Zhang J, Qin Y, Wei YX

Antioxidant production is reduced in patients with inflammatory bowel diseases, even before they begin to develop any symptoms

The synthesis of reactive oxygen species with the involvement of inflammatory response cells is carried out by enzymes such as NADPH oxidase

disruption of this pathway (which can be induced by low cofactor status) has a significant and negative impact on our ability to combat oxidative stress and inflammation