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The study by Teichman et al

Disruptions to Circadian Rhythms Influence on Ischemic Stroke (Basic Science) Disruptions to circadian rhythms prior to ischemic events leads to a prothrombotic state resulting in a heightened predisposition for enhanced stroke damage and poor outcome

This adds to the difficulty in reconciling MS under a single pathophysiological umbrella, but also has implications for therapeutic design: this cytodegenerative component is not expected to respond to current anti-inflammatory disease-modifying drugs targeting acute/adaptive peripheral autoimmunity

TB-500 Solution turned yellow: A slight yellow tint is normal