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Retatrutide (LY3437943) is a first-in-class triple-receptor agonist peptide developed by Eli Lilly that simultaneously activates three metabolic receptors: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and glucagon

Injectable b12 bypasses all absorption issues, providing 100 percent bioavailability regardless of stomach acid levels or intrinsic factor status

Oral semaglutide ($289/mo at PlexusDx) activates the same GLP-1 receptors and causes constipation through the same mechanism as injections

He regularly highlights the basics people often dismiss as too simple: getting outside drinking water moving your body sleeping more reducing stress These foundational habits anchored everything else