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This is particularly noteworthy because two competing oral small-molecule GLP-1 programs from Pfizer, lotiglipron (discontinued in 2023) and danuglipron (discontinued in April 2025), were terminated due to liver toxicity concerns

Crystal Broussard, MD, is a board-certified family physician and a Fellow of the American Board of Obesity Medicine

In a recent blog post, I wrote about How to eat if you take a GLP-1 Medication, where I outlined: what GLP-1 medications are how these medications work why GLP-1 Medications are gaining attention 6 key nutrition concerns for GLP-1 users GLP-1s and food noise, plus strategies to reduce food noise (regardless of GLP-1 use) What happens when I stop taking GLP-1s

If symptoms persist or become more severe, halting the GLP-1 receptor agonist dose titration and assessing the patient for the presence of underlying conditions may be advised