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Researchers at the University of Halle demonstrated that H89, a PKA inhibitor, could block retatrutide chronotropic effects but not those of isoprenaline (a beta-adrenergic agonist), confirming that retatrutide works through a distinct PKA-dependent mechanism rather than through the sympathetic nervous system

doi: 10.3233/JAD-130584 [DOI] [PubMed] [Google Scholar] 123.Ma DL, Chen FQ, Xu WJ, et al