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Collectively, these findings broaden the implication of biomaterial-based tolerance strategies by confirming that nanoparticles can effectively deliver diverse CNS autoantigens, including PLP, MBP, and AQP4, to re-establish antigen-specific immune regulation across multiple mechanistically distinct autoimmune diseases

The ipamorelin dosage used in medical settings and clinical trials is 0.03 mg per kg of body weight administered intravenously twice daily

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