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As of this time of this article, only the approval by The Centers for Medicare & Medicaid Services has taken place

The lowest effective dose in males (0.01 mg/kg) failed to significantly reduce alcohol-appropriate responding in females, suggesting lower sensitivity in females

This disruption triggers neuroinflammation, with the release of pro-inflammatory cytokines and reactive oxygen species, leading to further brain damage and contributing to the severe neurological symptoms characteristic of the disease, often resulting in death in the absence of treatment 14,15,16,17

Side effects like nausea, reduced appetite, and mild gastrointestinal discomfort are most common during this period and at each subsequent dose increase