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Understanding baseline predisposition markers can help providers optimize initial dosing strategy, potentially reducing side effects and improving adherence

Both 4-HNE and MDA are extensively studied markers of lipid peroxidation, with MDA recognized as a mutagenic product of lipid peroxidation and 4-HNE recognized as the most toxic product of lipid oxidation (104), worsening the damage resulting from oxidative stress (105, 106)

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1 Despite the concern about increased bleeding during periodontal and dental procedures in patients on anticoagulant therapy, 13,14 a number of clinical studies, 911 systematic reviews 12 and meta-analyses 13 found that continuing warfarin without any dose adjustment before dental procedures did not increase the risk of clinically important bleeding