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This suggests more robust or sustained expression and coordination among multiple CYP enzymes relevant to verapamil metabolism, including the metabolizing enzymes CYP2C8 , CYP3A4 and CYP3A5 , all of which are responsible for verapamil N -demethylation and were highly expressed in h-HepOrgs in DM (Extended Data Fig

Zhang, W., Miao, J., Zhang, G., Liu, R., Zhang, D., Wan, Q., Yu, Y., Zhao, G., and Li, Z

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