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Conversely, there was a 12.3% reduction in trials between P1 and P2

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Garczorz et al 67 found that GLP-1R agonists reduced endothelial cell MMP-1, MMP-2, and MMP-9 production and stimulated TIMP-1 and TIMP-2 synthesis by inhibiting TNF--induced activation of NF-B, suggesting that GLP-1RAs may play a role in the treatment of COPD by altering protease/antiprotease synthesis