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demonstrated for the first time that TMAO can bind and activate PERK to cause atherosclerosis, which provides a new mechanism of action of TMAO-induced atherosclerosis, which will be described in detail below ( Effect of TMAO and Its Precursor (L-CARNITINE) on Atherosclerosis TMAO and Atherosclerosis Atherosclerosis is the pathological basis of coronary atherosclerotic heart disease ( TMAO and Chronic Coronary Artery Disease In recent years, several studies have suggested that TMAO is a new independent risk factor for atherosclerosis (Table 1)

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The Y2 receptor is the primary target receptor for PYY(3-36)

Rose, R