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Glutathione is an important antioxidant in the lungs, but its concentration is low in the airways of patients with cystic fibrosis, since GSH is transported into the airways by the cystic fibrosis transmembrane conductance regulator, which is mutated in cystic fibrosis patients (111)

Elimination The metabolism of saxagliptin is primarily mediated by cytochrome P450 3A4/5 (CYP3A4/5)